New Book on Steroid use by Edith Garfield

Description

A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes which alter membrane fluidity; and as signaling molecules. Hundreds of steroids are found in plants, animals and fungi. All steroids are manufactured in cells from the sterols lanosterol (opisthokonts) or cycloartenol (plants). Lanosterol and cycloartenol are derived from the cyclization of the triterpene squalene.The steroid core structure is typically composed of seventeen carbon atoms, bonded in four "fused" rings: three six-member cyclohexane rings (rings A, B and C in the first illustration) and one five-member cyclopentane ring (the D ring). Steroids vary by the functional groups attached to this four-ring core and by the oxidation state of the rings. Sterols are forms of steroids with a hydroxy group at position three and a skeleton derived from cholestane.: 1785f  Steroids can also be more radically modified, such as by changes to the ring structure, for example, cutting one of the rings. Cutting Ring B produces secosteroids one of which is vitamin D3. Examples include the lipid cholesterol, the sex hormones estradiol and testosterone,: 10–19  and the anti-inflammatory drug dexamethasone.Garfield is an American comic strip created by Jim Davis. Originally published locally as Jon in 1976, then in nationwide syndication from 1978 as Garfield, it chronicles the life of the title character, Garfield the cat; Jon Arbuckle, his human owner; and Odie, the dog. As of 2013, it was syndicated in roughly 2,580 newspapers and journals, and held the Guinness World Record for being the world's most widely syndicated comic strip.Though this is rarely mentioned in print, Garfield is set in Jim Davis' hometown of Muncie, Indiana, according to the television special Happy Birthday, Garfield. Common themes in the strip include Garfield's laziness, obsessive eating, love of coffee and lasagna, disdain of Mondays, and diets. Garfield is also shown to manipulate people to get whatever he wants. The strip's focus is mostly on the interactions among Garfield, Jon, and Odie, but other recurring minor characters appearing as well. Originally created with the intentions to "come up with a good, marketable character", Garfield has spawned merchandise earning $750 million to $1 billion annually. In addition to the various merchandise and commercial tie-ins, the strip has spawned several animated television specials, two animated television series, two theatrical feature-length live-action/CGI animated films, and three fully CGI animated direct-to-video films. Part of the strip's broad pop cultural appeal is due to its lack of social or political commentary; though this was Davis's original intention, he also admitted that his "grasp of politics isn't strong", joking that, for many years, he thought "OPEC was a denture adhesive".On August 6, 2019, New York City-based ViacomCBS announced that it would acquire Paws, Inc., including the rights to the Garfield franchise (the comics, merchandise and animated cartoons). The deal did not include the rights to the Garfield films, which are still owned by The Walt Disney Company through its 20th Century Studios label. Jim Davis will continue to make comics, and a new Garfield animated series is in production for ViacomCBS subsidiary Nickelodeon.